This Article is About
genes
body tissues
stem cells
telomeres
gene expression
detrimental effects
Is Aging In Our Blood And Our Genes?
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"Getting old" is more than the accumulation of wrinkles, the passing of years and loss of physical activity. Aging takes a toll on all the tissues within our bodies, as we grow older day by day. It has demonstrated to have especially detrimental effects on the brain, which has been known to be composed of tissues with low regenerative power. After all the brain is the body's most vascularized organ which covers a large amount of surface area with a system of blood vessels that run through it. In the biomedical research literature it has been showed that muscle,liver tissue, and blood have a better capacity to renew themselves in the presence of young blood. It has been concluded that aging and the diseases that have come to be associated with it, as well as other conditions can be traced to the gradual increase in errors that occur during cell division in body tissues. This change starts around the time a person is in their middle age and increases with age.

There is something present in our blood which influences stem cells in many of our tissues. Depending on what cues they receive from their immediate surroundings, stem cells have the ability to multiply or produce differentiated daughter cells that can help renew tissues in need of repair.Mutations that take place in cell division can potentially cause the altering and expressing of a series of important genes in the cells. Altered gene expression can gradually cause the loss of tissue function which results in aging.

There is one genetic aspect of aging is the gradual degradation of our telomeres, repeating sequences of DNA that cap the ends of each chromosome. With each division of a cell, its telomeres become shorter and shorter until they are so short that the cell can no longer divide to reproduce or repair itself. Some cells that must divide often, including reproductive germ cells, produce an enzyme called telomerase that allows the cell to rebuild its telomeres, allowing continued division. There is a complicated system of many genes and proteins work together to gradually lead us and our cells towards gradual and inevitable aging.

It is estimated that genes can explain a maximum of 35 percent of lifespan. The other determinants are personal behaviors, exposures, and just perhaps just luck. In the end, aging is a complex interaction of genetics, chemistry, physiology and behavior.Some genes of the genes that help explain lifespan may be inherited from generation to generation. There may also exist mutations that may either increase or decrease a persons lifespan.


Street Talk

Very interesting article. Aging is definitely not for sissy's. I don't really understand about genetic aspects, but it is worth noting if we can do something about the other 65% through behaviors, exposures, etc., we should pay close attention to good behaviors and what we are exposed to. No smoking, limited alcohol, sun exposure as well as chemicals in everything we eat and drink could be some good behaviors.

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  about 7 years ago
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