This Article is About
national cancer institute
dna mutations
dna sequences
cancer cells
type of cancer
types of cancer
Genes And Cancer
Join 1000's of Authors at StreetArticles Today!

Genes And Cancer


A gene is not enough

For many years it was thought that one could find "the" cure for cancer. Then he realized that every type of cancer was a story in itself. Today, most experts believe that there is only one approach that applies to everyone, even for apparently similar diseases. The traditional distinction of tumors in relation to their home and the tissue from which they originate is not so obvious.

By examining in detail the molecular mechanisms underlying the formation of tumors, in fact, the researchers found that a particular type of cancer can be caused by several thousands of DNA errors. However, there are mutations that occur in different types of cancer and probably play a crucial role in triggering the process leading to the disease: that it is likely that soon there will be no cure for lung cancer or colon, but tumors by either mutation of the DNA, regardless of location in which they develop.

Finding errors

An important line of research is to find rapid methods, reliable and economic means to better analyze the DNA of cancer cells taken from the patient. From this identikit, many researchers are trying to make ever more precise, in the future will increasingly depend on the care that the patient will undergo. Already, for several targeted therapies, is the genetic analysis to predict who will benefit most from treatment, but other studies have found out who can take advantage of traditional chemotherapy is the case of two recent works, to Lisa Licitra, at ' National Cancer Institute of Milan, on tumors of the mouth and that of Bologna Katia Scotland, Ewing's sarcoma, both funded by AIRC.

Repair defects

The DNA mutations that promote cancer can be inherited from parents or induced by environmental factors of different types: Depending on the point of occurrence can trigger cancer by activating DNA sequences that directly or indirectly pushing the cell to replicate (oncogenes ) or by disabling DNA sequences that contrary to slow cell growth (tumor suppressor) or push her to suicide program called apoptosis.

Scientists are looking at ways to repair these errors or at least, knowing them, to find substances capable of counteracting the effects: for example, Paolo Comoglio Institute for Research and Treatment of Cancer Candiolo (Turin) will coordinate with the funds derived from the AIRC to 5 per thousand, a job that will also involve the Niguarda Hospital in Milan, will target two mutated genes, called MET and RON, which seem essential for the growth of metastatic tumors of the intestine.

Supporting the corrections

But there is also another very topical area of ​​research, followed by several researchers supported by AIRC, which emphasizes the importance of the so-called genomic instability in the genesis of cancer. Even in the DNA of a healthy cell because errors occur constantly in the process of duplication of chromosomes, but there are very efficient repair mechanisms that obviate the inconveniences suffered by avoiding harmful consequences. Sometimes cancer is triggered when these processes fail: research objective is to find a way to restore them and strengthening them. IFOM, Milan, for example, under the guidance of Marco Foiani, many researchers with the support of AIRC are responding to this challenge.

Small but effective

RNA, we study in school, used to translate the information contained in genes into proteins. But some small RNA sequences have a different function, regulatory type. Many laboratories and many young researchers, thanks to the contributions of the AIRC, focus their attention on the interference of these microRNAs and engaged in the production of key proteins for cell growth. In some types of cancer, such as lung and stomach cancer, and mesothelioma in some leukemias, but also in multiple myeloma, their role has been confirmed: it remains to understand how to use them to treat cancer.

Above the DNA

Another important line of research began with the discovery that the expression of several genes can be modulated by molecules that attach externally to the DNA. It is epigenetics, know better what is hoped to be able to deal more blows to the indiscriminate growth of cancer cells: from Rome to Florence, there are various projects that the AIRC is funding in this field.

Street Talk

Thanks for share this usefull information

  about 6 years ago
You May Also Like
The Health Benefits Of Chlorella And Which Supplement To Buy
Chlorella is a food with many health benefits, in fact many consider it to be a Superfood. Chlorella is a single-celled algae that can serve as a complete protein source for strict vegetarians. Included in its many health benefits are detoxification, it’s richness in vitamins, minerals and carotenoids and when…
By: Lenore in  Health and Fitness  >  Supplements   Feb 18, 2014  
  Likes: 2

Obesity And Cancer: The New Link Between the FTO Gene And Increased Breast Cancer Risk
Science has known for some time that obesity ups a person’s risk of a number of different cancers, and have been warning about that for years. But, despite all of the studies and the reports, the obesity numbers just keep climbing and unfortunately for the nation, so does the rate…
By: Jacey Figgins in  Cancer   May 24, 2011  
  Likes: 0

Food As Medicine
Today many people think that food is just fuel for our body, and forget the old saying,“you are what you eat“. We all pile tones of unhealthy food in our bodies, and are not aware of consequences such as various illnesses: heart disease,vascular disease, diabetes, cancer and many others. The…
By: Marko Mustac in  Health and Fitness  >  Foot Health   Dec 26, 2013  
  Likes: 8

Is Cancer Just A Number?
How many people do you know that have been touched by cancer? How many of you have been touched by cancer? The statistics are quite mind boggling when you look at them. As of January 2008, the National Cancer Institute estimated that there are nearly 12 million U.S. citizens living…
By: Joseph Primm in  Cancer   Mar 13, 2012  
  Likes: 2

Cancer Screenings Falling Short Of Targeted Goals In Nearly All Categories
A new federal study, undertaken by the Center for Disease Control and Prevention along with the National Cancer Institute has shown some troubling numbers when it comes to cancer screening. Focusing on three different types of common cancer, the study looked at the information from a 2010 survey which asked…
By: amie nogrady in  Cancer   Jan 31, 2012  
  Likes: 0

Tanning Beds Or Cancer
Are Tanning Beds Safer Than Natural Sun? With all the emphasis on safe sunning and the dangers of ultraviolet rays, many people have chosen to get a healthy tanning glow in what may actually be a most unhealthy way – the use of a tanning bed or tanning salon. Statistics…
By: Gary2 in  Cancer  >  Skin Cancer   Jul 18, 2011  
  Likes: 1

Coffee Enemas to Treat Cancer
In a nutshell, a coffee enema is related to the procedure wherein the coffee is inserted into the anus. Moreover, the enema procedure has also been used for many years to treat illnesses like encopresis, constipation and other medical condition. Recently, it is being promoted as the coffee enemas to…
By: Sunny Walters in  Cancer   Jun 22, 2011  
  Likes: 3

Coffee Enemas Liver Detox
Our environment contains a lot of toxins and the sad thing is that we are not fully protected from this. Hence, our body still receives toxins through drinking, eating, smoking, breathing and many more. What we need to do then is nothing but to regularly detoxify our body from these…
By: Sunny Walters in  Health and Fitness  >  Detoxification   Jun 22, 2011  
  Likes: 0

Treatments for Lung Cancer - Recommended Treatments for Lung Cancer
When you are asked which kind of cancer has killed the most people, your natural response would be to blurt out breast cancer. Wrong! Lung cancer is the grand champion, by a mile. Close to 200,000 Americans are diagnosed with lung cancer every year. One of the main causes, although…
By: John Daniel Rivera in  Cancer  >  Lung Mesothelioma Asbestos   Dec 22, 2011  
  Likes: 1

Skin Cancer Diagnoses on the Rise: Most Preventable Form Of Cancer is Often Most Overlooked
A new study by the Mayo Clinic reveals some troubling news about skin cancer and the number of people who die from it every year. That study shows a dramatic rise in the number of cases of melanoma with numbers of new cases increasing by four times for men ages…
By: amie nogrady in  Cancer  >  Skin Cancer   May 23, 2012  
  Likes: 1

Green Tea for Weight Loss
Green tea has a long history in the Asian market where the Chinese people have known the benefits from it for more than 4000 years. In the western world we have mostly used black tea but are getting more and more into the little green leaves from Asia. This wonder…
By: Thom in  Health and Fitness  >  Weight Loss   Sep 16, 2013  
  Likes: 4

Coconut Oil for Health Benefits
Much has been documented about the health benefits of coconut oil. The problem lies is in the mainstream medical establishments disagreement with these claims. Knowing the reason behind the mainstream opinion helps to understand why something that scientifically has been proven helpful would be regarded in a negative light. With…
By: Jonathan Hughes in  Health and Fitness  >  Nutrition   May 22, 2013  
  Likes: 0

Do Mammograms Save Lives?
Women have been told for over twenty years that mammograms save lives. Most of them believe it and spend most of their adults lives scheduling mammograms, having mammograms, waiting for results and often having painful, nail-biting follow ups that usually do not reveal any cancer. Do Mammograms Save Lives? Breast…
By: Jane Eyre in  Health and Fitness  >  Womens Issues   Jan 09, 2012  
  Likes: 4

Are Coffee Enemas As A Liver Flush Safe And Effective
A lot of people are actually skeptical about using coffee enemas as a liver flush treatment. Well, I cannot blame them if it is their first time to hear about the concept. Enemas are kind of a touch subject for some people, and using coffee for an enema can sound…
By: Sunny Walters in  Health and Fitness  >  Detoxification   Jun 24, 2011  
  Likes: 4

Coffee Enemas Liver Cleanse
There has been a lot of research done already pertaining to the effects of coffee on our health and body. Some of these benefits are related to the health of our skin, digestion and even detoxification. The latter has been controversial recently due to public and professional inquiring. As a…
By: Sunny Walters in  Health and Fitness  >  Detoxification   Jun 24, 2011  
  Likes: 0

Article Views: 2843    Report this Article